This aligns with findings from SURPASS-CVOT, which showed no meaningful additive effect on MACE compared to an older GLP-1 receptor agonist, and with findings of a potential greater protection in heart failure that could be compatible with more pronounced weight loss mediated by GIP 16,22
Persistent fatigue Emotional stress Increased appetite Compromised mobility Low mood/anxiety Difficulty with weight regulation Low self-esteem Sleep disturbances **Average weight-loss results cited (21% for tirzepatide and 1516% for semaglutide) are based on peer-reviewed clinical trials published in leading medical journals, including The New England Journal of Medicine
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