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5.1 Potential effects of ammonium metabolism on various components in the TME of prostate cancer As integral components of the TME, tumor-infiltrating immune cells (TIICs) can significantly alter the immune landscape of tumors (257259)

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In atherosclerosis susceptible regions, reduced expression of eNOS and SOD leads to compromised endothelial barrier integrity (Figure 1), leading to increased accumulation and retention of subendothelial atherogenic apolipoprotein B (apoB)-containing lipoproteins (low-density lipoproteins (LDL)) and remnants of very low-density lipoproteins (VLDL) and chylomicrons) (21,22)

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