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HS usually emerges in adolescence and is recurrent (216)

(2016) suggested that the antipsychotic drug paliperidone may mitigate OS by upregulating nuclear factor erythroid 2-related factor 2 (Nrf2) in the Phosphoinositide 3-kinase/Protein kinase B (PI3K/AKT) pathway

Acts as a powerful anti-inflammatory agent by reducing the production of cytokines (pro-inflammation)

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These include environmental factors, such as ultraviolet (UV) radiation and environmental pollutants, including ozone and cigarette smoke (115, 116)