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however, unlike classical ligand-regulated receptors, NHR-49 is regulated through ligand-independent mechanisms involving cofactor-mediated transcriptional attenuation and protein turnover

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Chronic alcohol use lowers the threshold for acetaminophen toxicity by induction of CYP enzymes and depletion of glutathione stores (Amar 2007)

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Spanier B., Rubio-Aliaga I., Hu H., Daniel H