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this is consistent with the fact that previous large clinical trials have not reached a conclusion on whether cardiovascular disease can be suppressed by strict glycaemic control [6]

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Autocrine GH for instance, is thought to be more oncogenic than pituitary GH, and the autocrine/paracrine IGF1 is the main determinant of postnatal body growth, including muscle and bone tissue development, confirming the conclusion that pituitary GH and circulating IGF1 are critical for body size and affect numerous body functions, for these body functions, local GH and IGF1 may be more relevant