Indigestion and other gastrointestinal symptoms typically peak during the first few weeks of treatment or after dose increases, then gradually diminish as the body adapts to the medication
The Bottom Line Heartburn on a GLP-1 isn't inevitable, but it is common and manageable
Nature 626 , 635642 (2024)
These results highlight semaglutides early action on decreasing major cardiovascular events, with significant benefits already evident by the first six months, and for some, even earlier, even before any major weight loss and before most patients would have been titrated to their full target dose of 2.4 mg, lead author Jorge Plutzky, MD, director of preventive cardiology with Brigham and Womens Hospital, said in a statement
[42] Additional effects [edit] Semaglutide typically causes a benign increase in resting heart rate (around 3 beats per minute), which has not been associated with adverse cardiovascular events