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One group, mapping to innate immunity and antiviral responses (Oas2, Oas3, Mx2, Irf7, Irf9, STAT1, il1b), required GSH for optimal induction

By inhibiting the expression of HDACs, TSA promotes the transformation of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages and reduces the infiltration of M2a macrophages

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In addition to taxonomy, shotgun metagenomics sequences all the DNA in a sample, providing a comprehensive view of the functional gene potential of entire microbiome and identifying genes involved in nitrogen fixation ( nifH ), phosphate solubilization ( pqq , gcd ), siderophore production (pvd), and antibiotic synthesis ( phz ) 38