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These medications may suppress appetite and reduce cravings, but they don't automatically rewire the brain's response to stress, anxiety, or other emotional triggers that lead to comfort eating

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10.1016/S1474-4422(17)30371-X [DOI] [PubMed] [Google Scholar] Maas A

Conversely, studies have shown that both patients and healthcare professionals are reluctant to initiate GLP-1RAs [11, 12], despite the guideline recommendations and the health benefits of these therapies, particularly for patients in need of weight loss and those with low estimated glomerular filtration rate [1]