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Current safety data for 5-amino-1MQ appears favorable for short-term use (8-12 week cycles), with no significant toxicity observed in preclinical studies at therapeutic doses

No Safety Evidence for the Proposed Subcutaneous Route FDA reported that it did not identify safety data for emideltide free base or emideltide acetate administered through the nominated subcutaneous route

The 2022 Dimet-Wiley paper in Scientific Reports characterised NNMT inhibition combined with reduced-calorie diet in diet-induced-obesity mouse model systems (PMID 35013352)