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Funding This work was supported by a R01MH128311 and a R56MH125895 to CN

In fact, pernicious means gradual harm. However, pernicious anaemia is easily treated with vitamin B12 supplements

The Neurovascular Link: From a mechanistic standpoint, this reinforces the "vascular hypothesis" of neurodegeneration

As an example, in a rat model of -synuclein induced ER stress, in the absence of re-establishment of ER homeostasis, ATF6 activates proapoptotic CHOP protein in DA-ergic neurons

Hence, identifying elevated concentrations of particular microparticles can be a significant prognosticator of vascular impairment and cardiovascular consequences