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3 Papillary thyroid cancer risk factors The incidence of PTC has been steadily increasing over the past few decades worldwide ( 4 Warburg effectthe novel target in PTC clinical management Literature data has indicated that molecular alterations within signaling pathways, such as RAS, RAF, and mitogen-activated protein kinase (MAPK), play a role in the development of thyroid neoplasms (Figure 1 (Figure 1)

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