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By lowering plasma glucose through renal excretion and modestly increasing circulating ketone availability, SGLT2 inhibitors shift systemic and cerebral energy metabolism away from exclusive dependence on glucose [27]

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Bei Gewebeverletzungen wird es aus Kollagen und anderen Matrixproteinen freigesetzt, wo es als Fragment der alpha-2-Kette des Typ-I-Kollagens entsteht Pickart et al., 2018