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No large clinical trials have directly studied berberine + GLP-1 co-administration in humans, so robust safety data is limited
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[4] [5] For weight management, NICE technology appraisals (TA875 for Wegovy, TA664 for Saxenda) specify these treatments should be used within specialist weight management services (tier 3 or 4), with specific eligibility criteria, time-limited use, and defined stopping rules
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