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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

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At launch, they might not be significantly cheaper if the technology involved in oral delivery is still expensive to produce. This will impact the industry tremendously Of course, if FDA approved, GLP-1 pills could drastically open up the market for these kinds of therapies