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For certain analyses, participants from the HC and SCD groups were combined into a single group of cognitively normal (CN), while those with MCI and dementia were grouped together into a cognitively impaired (CI) group

CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle

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Tran KC, Hiremath S

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