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Neither compound shows a clear safety advantage at this stage, though semaglutide has far more long-term data behind it

Aronne LJ et al., SURMOUNT-5 head-to-head, NEJM 2024 (NEJMoa2416394) : tirzepatide vs semaglutide, advantage tirzepatide of approximately 6 points

TIER 1 (40mg total) $370 total for 8-10 week supply Monthly cost breakdown: $148-$185 based on weekly dose Recommended if new to treatment or for those on 2-5mg/week TIER 2 (60mg total) $445 total for 8-10 week supply Monthly cost breakdown: $178-$220 based on weekly dose Recommended for those on 6-7mg/week TIER 3 (80mg total) $575 total for 8-10 week supply Monthly cost breakdown: $288-$292 based on weekly dose Recommended for those on 8-10mg/week TIER 4 (120mg total) $725 total for 8-10 week supply Monthly cost breakdown: $290-$363 based on weekly dose Recommended for those on 11mg/week and up Custom Semaglutide Injectables Custom-compounded Semaglutide injectables are expertly formulated by our partner pharmacies to support your personalized wellness and weight management goals

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Women may experience rebound weight gain when discontinuing semaglutide or having a missed dose for prolonged time