Reduction of intracellular GSH alone did not activate the ISR and cystine starvation induced a robust ISR which was not aggravated by BSO treatment (Fig
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Based on these data, pivotal phase 3 trials comparing icotrokinra with placebo in participants aged 12 years and older with moderate-to-severe plaque psoriasis [ICONIC-LEAD (NCT06095115)] and plaque psoriasis involving difficult-to-treat high-impact sites including scalp, genitals, and hands/feet [ICONIC-TOTAL (NCT06095102)], have been initiated (Table 3)
