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Related parameters of ROS-formation in PBMC were not significantly affected by L-carnitine supplementation, but were strongly influenced by LPS administration, as shown in Supplementary Figure 4

Secondly, the redox status of the cell affects many of the enzymes in one-carbon metabolism including MATI, MATIII, MS, BHMT, as well as CBS and GCS in the transsulfuration pathway, and therefore one cannot evaluate GSH metabolism without including the methionine and folate cycles

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