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However, GSH depletion is a most characteristic finding when red blood cells are subjected to oxidative challenge, and in one careful study it has been demonstrated that during an attack of favism, the first measurable biochemical change is a decrease in NADPH, followed by a decrease in GSH, in keeping with stages 1 and 2 described earlier

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Glutathione plays an important role in protecting cells from free radical damage and in detoxifying heavy metals and other pollutants