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Contrave is FDA-approved for chronic weight management in adults with a BMI of 30 or higher (obesity), or a BMI of 27 or higher with at least one weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol

Downregulation of the activity of a number of CoA-dependent acyltransferases has been reported in HSL-null mice, and it is believed to contribute to maintenance of normal weight in the face of complete ablation of this important lipolytic enzyme (144)