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Common risk factors for NAION include: Diabetes High blood pressure High cholesterol Sleep apnea Small or crowded optic nerves Smoking Cardiovascular disease Older age These risk factors are important because many patients who take GLP-1 medications may already have diabetes, obesity, sleep apnea, or vascular risk factors that can also increase NAION risk

Vitamin D-induced molecular mechanisms to potentiate cancer therapy and to reverse drug-resistance in cancer cells

GLP-1 medications may not be suitable for individuals with: History of pancreatitis (not recommended per UK SmPCs) Severe gastrointestinal disease or gastroparesis (caution advised) Diabetic retinopathy, particularly for semaglutide (requires monitoring) Pregnancy, planning pregnancy, or breastfeeding (contraindicated

(a) is it appropriate to view liver in isolation, when MASLD IS NOT an ISOLATED Disease

It catalyses the hydrolysis of the fatty acids in the 2 or -position of the phospholipids