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For a long time, the prevailing view was that oral glutathione is poorly absorbed that the digestive tract breaks the tripeptide down before it can reach the bloodstream intact

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The GST tag can easily be removed following purification by addition of a protease if a suitable protease-cleavage site has been inserted between the GST-tag and the protein of interest (which is usually included in many commercially available sources of GST-tagged plasmids)