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These findings exemplify the inconsistencies over time in the different studies regarding the appearance of glomerular hyperfiltration in patients with preDM, which would even be influenced by the criteria used for its diagnosis,32 in addition to ethnic differences, limited population, and lack of availability in the reference ranges in relation to age, sex and race for eGFR estimation.22 In a Japanese cohort, when analyzing 5003 patients with preDM, the risk of developing glomerular hyperfiltration was approximately 25% higher

Further, the mechanical properties of GO are also influenced by its layered structure

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