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In adipocytes lacking CI, we observed reduced expression of genes involved in the response to insulin stimulus and PI3K/protein kinase B signal transduction (Fig

This process is driven by the failure of cellular antioxidant defenses, particularly the GPX4 system, which neutralizes typically lipid peroxides using glutathione (GSH) [86, 87]

Med 23 , 120127 (2017)

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Thus, the levels of mitochondria-related metabolites, such as pyruvate, carnitine, and ubiquinone in the blood of children diagnosed with ASD appeared to be significantly different from those of their typically developing peers [35]