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D., Huang, B.-W

While GLP-1 medications are primarily indicated for Type 2 diabetes and chronic weight management in adults with obesity or overweight, they continue to be approved for new indications, expanding their reach

GLP-1 is involved in migraine mechanisms and GLP-1R agonists are beneficial in individuals with idiopathic intracranial hypertension

The most common retatrutide side effects are nausea (28%), diarrhea (24%), constipation (21%), and vomiting (17%), with symptoms peaking around weeks 6-8 before substantially improving by week 12

In a previous systematic review of weight regain following behavioural weight management programmes, Hartmann-Boyce et al (2023a) identified that, after a mean weight loss of 2.4 kg, weight regain occurred at a rate of 0.02 kg per month, with evidence of cardiometabolic benefit persisting for 5 years