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In clinical applications, numerous natural compounds, acting as endogenous activators of NRF2, demonstrate significant potential in alleviating intestinal disorders by promoting nuclear translocation and the expression of downstream antioxidant and anti-ferroptotic genes ( Uncontrolled lipid peroxidation is a hallmark of ferroptosis, with Acyl-CoA synthetase long-chain family member 4 (ACSL4) playing a central regulatory role in this process

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This overview is intended to contextualize existing findings, without suggesting subtype-specific therapeutic applications (Table 1)