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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye allows for testing of any otic formulation described herein in human clinical trials

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In addition, we treated PC cells with monensin to make SLC7A11 remain in Golgi and trace its expression upon monensin removal

They are typically administered via subcutaneous injections (into the tissue under the skin) and are used along with lifestyle modifications, such as a balanced diet and regular exercise