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Only vitamin E supplementation significantly increased the overall rate of improvement in histological abnormalities that characterize MASH on liver biopsies (i.e., hepatocellular ballooning, steatosis, and lobular inflammation) (98)

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This supports the hypothesis about the hemolysis-preventing role of eryptosis, since detrimental internal or external perturbations triggering eryptosis might continue to act, overcoming the adaptive capacity of cells, causing lysis

When interpreted with a qualified healthcare provider, these predispositions can help explain why some patients respond robustly to GLP-1 therapy at lower doses, while others may require higher doses or combination approaches

Lifestyle Factors: Reduced physical activity or stress-related eating can contribute