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Notably, our lead compound KL1 reduced ROS/RNS production in macrophages, sensitized intracellular persisters to antibiotics, and enhanced antibiotic efficacy in murine infection models
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(1991) Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit
Occurred in 11% of the 50mg group and 14% of the 100mg group, compared to 6% in placebo
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