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Currently, the majority of systematic reviews are devoted to the impact of GLP-1 receptor agonists on the effects on weight and metabolism causes, although there is still no systematic evidence of their psychiatric adverse effects [23].Specifically, since depression is a mental consequence with the low incidence rate and is affected by a variety of determinants, its evaluation demands higher level of statistical power and analysis of studies across different studies [24, 25]

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This means they are safe and legal for use in weight management in the UK