glp 1 timeline Another milestone in the evolution of GLP-1-based diabetes therapies Timeline of GLP-1 discovery and

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Thus, increased DA and early changes in energy metabolism impact neuronal viability before symptom onset in Trkb Penk -KO mice

In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions

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Several agents have shown efficacy in reducing triglyceride levels and also in reducing cardiovascular disease risk