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Witschi A, Junker E, Schranz C, Lauterburg BH

KPV Proposed use : wound healing and inflammatory conditions Outcome : Yes Margin : 8-6 in favor, with one abstention What the FDA was saying : The nominator did not provide clinical evidence for that proposed use, and lacked human studies

This was mainly related to the reduction in populations III and IV, corresponding, respectively, to polychromatic erythroblasts and orthochromatic erythroblasts (Supplemental Figure 4E)

Furthermore, ACA suppressed the expression of Th2 cytokines (IL-4, IL-6, and IL-13) and Th1 cytokines (IL-12 and IFN-) in the ACA-treated group in a dose-dependent manner