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CoQ 10 is also an obligatory cofactor of mitochondrial uncoupling proteins, which regulate ATP production and reduce free radical generation (Echtay et al

"Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin." Disease Management & Clinical Outcomes , 1998

NICE guidance emphasises the importance of regular physical activity, maintaining a healthy weight, reducing alcohol consumption, stopping smoking, and managing stress

some are benign but some carry pre-cancerous risk and warrant biopsy Malignant lesions: Squamous cell carcinoma (SCC) the most common lip cancer