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In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]

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130,131,132 USP7 improves insulin sensitivity and suppresses gluconeogenesis, offering another example of a DUB with beneficial effects on glucose homeostasis