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PD-1 is highly expressed in infiltrating lymphocytes in various tumors, and PD-1 ligands are often upregulated on the surfaces of tumor cells and inhibit the local antitumor immune response mediated by T cells (159)

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Adv Drug Deliv Rev 60:15451552 Rebrin I, Kamzalow S, Sohal RS (2003) Effects of age and caloric restriction on glutathione redox state in mice

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