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The discrepancy between blood and muscle was studied in individuals undergoing major abdominal surgery

SARS-CoV-2 could invade blood vessels, induce vascular damage, and activate systemic thrombotic events with severe to fatal coagulopathies in COVID-19 patients 100

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For systemic research, certain contraindications exist, such as pregnancy, breastfeeding, active cancer, or conditions like Wilsons disease (a genetic disorder causing copper accumulation)