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Hyperactivation of ERK plays an important role in cancer progression

Studies have shown that p53 can induce ferroptosis by inhibiting SLC7A11 transcription and upregulating ALOX15 [71, 72]

doi: 10.1021/jm800824d 169 ItoIWakuTAokiMAbeRNagaiYWatanabeTet al

Safety of the patients was maintained by discontinuing subjects that were asymptomatic with a fasting glucose over 180 mg/dL or symptomatic with a fasting glucose lower than 180 mg/dL, in order to account for hyper- or hypersensitivity reactions