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Afferent and efferent innervation of the hindbrain GLP-1-producing neurons Unlike many of its gut or fat hormone counterparts (ghrelin or leptin) for which there is little evidence of central production, GLP-1 can be made in the brain

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TMAO is identified as a metabolite significantly associated with Alzheimers disease (AD) aspects and shares genetic pathways with AD biomarkers (141)