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Glutathione depletion impacts the gamma glutamyl cycle in the liver by increasing the activity of -glutamyl cysteine synthetase and accumulation of -glutamyl cysteine, which is converted by -glutamyl cyclotransferase to pyroglutamic acid/5-oxyproline [3, 4] (Fig

In addition, ROS will cause mitochondrial dysfunction, and more ROS are produced, causing lipid peroxidation of the cell's lipid contents with MDA liberation.[] Therefore, in this study, MTX increases MDA hepatic tissue level more than four-fold compared to the control group

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10.3389/fendo.2021.639165 58 GuptaP.SharmaG.LahiriA.BarthwalM

IGF-LR3 1mg IGF1 LR3 also known as Long R3 IGF-1 or Insulin-Like Growth Factor-I LR3 is a Human Recombinant, single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9200 Daltons