In mice, inhalation of cigarette smoke has been shown to increase peripheral cathepsin D expression and activity 58 as well as HIF-1 and HO-1 expression 59,60

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They drive impulse purchases
Lewis, Judges Turn Back Law to Regulate Internet Decency, New York Times, June 13, 1996
More accurate estimates of the size of the illicit market separately attributable to tax avoidance and tax evasion could be obtained by combining more systematic data collection on discarded packs in states with significant illicit trade with (1) an expansion in the number and specificity of questions currently asked in representative population surveys regarding tobacco use and illicit tobacco market participation and (2) a large-scale pack swap survey that is similarly representative of the U.S