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Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease

6 One should be wary of formulating and dispensing these medicines, as compounding errors in semaglutide administration have caused severe adverse effects, as Lambson and colleagues 8 reported in a case series

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Sun F, Wu S, Wang J, Guo S, Chai S, Yang Z, Li L, Zhang Y, Ji L, Zhan S: Effect of glucagon-like peptide-1 receptor agonists on lipid profiles among type 2 diabetes: a systematic review and network meta-analysis