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In asthma patients, a correlation has been found between the degree of bronchial responsiveness to methacholine and the production of superoxide anion by peripheral polymorphonuclear leukocytes (28,29)

But a lot of it comes down to oxidative stress quietly accumulating beneath the surface

KEGG pathway analysis of downregulated (upper panel) and upregulated (lower panel) genes in Bmal1 -KO vs

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Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography