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Understanding this pathway is essential for safe medication use and personalized health decisions

Although some promising results have been observed in animal models, it is not known whether supplementation with thiamin or benfotiamine (a synthetic precursor of thiamin) might slow the cognitive decline in patients with Alzheimers disease

Apoe + monocyte-derived macrophages supplied alveolar macrophages and helped to maintain their phenotype stability via the Apoe-Trem2 axis

Dopamine could also potentiate ATP-induced secretion of IL-1 but did not mediate the secretion of IL-1 on its own, which indicates that dopamine can prime but not activate the NLRP3 inflammasome by activating NF- B (Nolan et al., 2020)