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The mixture was stirred under a hydrogen atmosphere for 20 h at r.t., then 4 h at 50 C, filtered, and evaporated to dryness under vacuum at 40 C to produce cyclopeptide 13 (7.0 g) as bis-trifluoracetate salt

APX (EC 1.11.1.11) activity was assayed according to the method of Nakano and Asada [52]

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Sermorelin mimics GHRH and acts on the pituitary directly

Because the nasal mucosa (the lining inside the nose) is highly vascular, it can allow fairly steady absorption of certain peptides into circulation without the need for an injection