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While GLP-1 and GIP signalling primarily enhance insulin secretion and modulate appetite, glucagon receptor activation increases hepatic glucose output, stimulates lipolysis in adipose tissue, and promotes thermogenesis

We found that GLP-2R has the most protruded ECL1 with a height of 22.6 and this ECL1 closely attaches to GLP-2 with the largest interface area of 791 2

Abstract Alcoholic liver disease (ALD) is a global health concern caused by chronic excessive alcohol consumption, and dietary intervention is a key strategy for improving ALD