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Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis

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Immunotherapy trials (Immune-Modulating Approaches) The most significant recent clinical advance has been the development of Teplizumab, an anti-CD3 monoclonal antibody

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On the other hand, the protein levels of poly(rC) binding protein 2 (PCBP2), the iron transporter protein involved in processes that include ferroportin-1 and herme oxygenase, were significantly higher in RSL3-treated compared to untreated isogenic brain organoids ( p = 0.045) (Fig