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Journal of Cellular Physiology, 236 (5), 34063419

This review provides a comprehensive overview of the characteristics and types of free radicals, their mechanisms of formation, and biological impacts

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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload