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As a result, increased stiffness triggers the translocation of the transcription factor co-activators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to the nucleus where they interact with the transcriptional enhanced associate domain (TEAD) family of transcription factors to induce gene expression [85]

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In long COVID patients, common GI symptoms include: Abdominal pain (29.2%), dyspepsia (29.2%), diarrhea (10%), constipation (11%), nausea/vomiting (7%), and heartburn (16%) remain present at 6 months in 43.8% of patients who did not have these symptoms before COVID-19