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However, studies on targeted segments of the population have shown that the upper limit of 15mol/L is far too high in well-nourished populations without obvious vitamin deficiency

For experiments involving alterations to the culture medium, cells were seeded in regular RPMI 1640 with 5% dialysed FBS (Gibco, 26400044) and 1% penicillin and streptomycin

They are often used early when a source isn't yet identified, but the human evidence for clinically meaningful chelation is thin

Gastrointestinal issues

This property is exploited by cancer cells, which develop a strong dependence on iron to satisfy the heightened metabolic demands associated with their uncontrolled proliferation and invasive behavior