Cagrilintide-semaglutide in adults with overweight or obesity and type 2 diabetes
However, the goal of glucose-lowering therapy extends beyond controlling blood glucose levels and body weight, encompassing the reduction of long-term cardiovascular complications
Medical Evaluation Investigate potential medical contributors to weight loss resistance: Thyroid function: Check TSH if not recently assessed, as hypothyroidism impairs weight loss Medications: Review for weight-promoting drugs (antipsychotics, certain antidepressants, corticosteroids) Sleep disorders: Screen for sleep apnea and insufficient sleep, both associated with weight loss resistance Stress and cortisol: Chronic stress elevates cortisol, promoting central adiposity and metabolic dysfunction Dose Optimization If patients have not reached the maximum tolerated dose, consider further titration according to FDA labeling
Some experts feel that this extra hormonal pathway could be the missing link for people whove had limited or no success with tirzepatide
This is true for GLP-1s including Semaglutide and Tirzepatide as with just about any other weight loss method because the body tends to shed muscle when there is less demand for it
